Dosage ; 10-40mg nocte. Adjustment of the doses done at intervals of above 4 weeks.
Combinations ; - see below
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Locol | Popular Pharmaceuticals Ltd | Madawa Pharmaceuticals Ltd. | 10mg | 30 | Tablet | per tablet | KES 323 |
| Zistatin | Cosmos Limited. | Cosmos Limited | 10mg | 30 | Tablet | per tablet | KES 300 |
| Zistatin | Cosmos Limited. | Cosmos Limited | 20mg | 30 | Tablet | per tablet | KES 570 |
| Simva-denk | Denk Pharma | Laborex Kenya Eurapharma Ltd | 20mg | 30 | Tablet | per tablet | KES 988.23 |
| Simva-denk | Denk Pharma | Laborex Kenya Eurapharma Ltd | 40mg | 30 | Tablet | per tablet | KES 1,364.70 |
| Simvastatin More info | |
|---|---|
| Mode Of Action | 3-hydroxy-3 methylglutaryl co-enzyme A (HMG-COA) reductase - the enzyme inhibitor which catalyses the early rate limiting step in cholesterol biosynthesis-conversion of HMG-Co A to mevalonate. |
| Drug Indication | Adjuvant to diet in primary hypercholestrolaemia; homozygous familial hypercholesterolemia. |
| Precautions | Monitor liver functions; heavy alcoholics; if myopathy is diagnosed or suspected discontinue; the possibility of toxic reactions should always be explained to the patient before the beginning of therapy. |
| Contra-Indications | Pregnancy and lactation; hypersensitivity; active liver disease or unexplained persistent defects in liver function tests; children under 18 years; impaired renal functions. |
| Side Effects | GI disturbances; myopathy; insomnia; UTI; tooth disorders; sinusitis. |
| Dosage | 10-40mg nocte. Adjustment of the doses done at intervals of above 4 weeks. |
| Pregnancy Category | Category C |
| Pregnancy Category Description | Drugs which, owing to their pharmacological effects, or may be suspected of causing detrimental effects on human foetus or neonates without causing malfunctions. These effects may be reversible |
| Drug Category | DRUGS ACTI NG ON THE CARDIO-VASCULAR SYSTEM |
| Drug Sub-Category | Statins |